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The genetics and epigenetics of extreme healing: hypertrophic scars and diabetic ulcers (337.4)
Author(s) -
Gibran Nicole
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.337.4
Subject(s) - medicine , wound healing , scars , epigenetics , disease , bioinformatics , hypertrophic scar , hypertrophic scars , fibroblast , diabetes mellitus , pathophysiology , translational research , pathology , surgery , in vitro , biology , endocrinology , gene , genetics
Hypertrophic scars and non‐healing diabetic ulcers represent wound complications on opposite ends of a continuum of healing. In spite of years of research, few breakthroughs in understanding the pathophysiology or developing therapeutic advances have relieved patient misery and health care costs for either chronic disease. We combine in vitro endothelial studies and an in vivo diabetic murine model to elucidate epigenetic effects of a high fat Western diet on diabetic wound healing and cellular responses. We use in vitro fibroblast studies, a porcine model of fibroproliferative scarring and a translational clinical trial to correlate single nucleotide polymorphisms with long term scarring after burn injury. Together these approaches offer novel perspectives on cutaneous responses to injury.