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Influence of dose and intensity of 6 months of aerobic exercise training on body composition and lipid profiles in participants with pre‐diabetes (272.2)
Author(s) -
Starr Kathryn,
Bales Connie,
Granville Esther,
Slentz Cris,
Bateman Lori,
Willis Leslie,
Piner Lucy,
Kraus William
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.272.2
Subject(s) - medicine , weight loss , aerobic exercise , endocrinology , lean body mass , cholesterol , diabetes mellitus , chemistry , composition (language) , zoology , body weight , obesity , biology , linguistics , philosophy
The Studies Targeting Risk Reduction Intervention through Defined Exercise (STRRIDE) compared exercise of varied dose/intensity to the “gold standard” of diet + exercise as used in the Diabetes Prevention Program (DPP). The findings for body composition and lipid responses to 3 exercise treatments, low dose/moderate intensity (LMEX; n=36), high/moderate (HMEX; n=34), and high/vigorous (HVEX; n=36) relative to weight‐loss diet+ LMEX (D+LMEX; n=41) are reported here. The D+LMEX reached the same weight loss as DPP at 6 mo., namely 6.6% (‐6.1+5.0 kg). Body mass changes were ‐0.9+3.3, ‐2.1+2.5, and ‐1.6+2.5 kg for LMEX, HMEX, and HVEX, respectively. The corresponding reduction in body fat was greatest (p<0.05) for D+LMEX (‐6.1+5.0 kg). Lean mass varied <1 kg and both LDL and total cholesterol were unchanged. HDL cholesterol increased equally (p<0.05) in D+LMEX (+2.3+6.1 mg/dL) and HVEX (+2.2+4.4 mg/dL) and also improved in HMEX (+1.6+4.6 mg/dL). Only D+LMEX (p<0.0001) and HVEX (p<0.05) reduced triglycerides (TG); however, D+LMEX had a greater reduction (p<0.05) compared to HVEX (‐28.3+34.7 vs ‐16.7+45.4 mg/dL). In summary, body weight, fat mass, and TG were most robustly improved by D+LMEX. HDL cholesterol was modestly increased in all groups but LMEX. These findings illustrate the importance of matching exercise prescription to the clinical goal and underscore the unique metabolic benefits of diet‐induced weight loss. Grant Funding Source : Supported by NIDDK R01‐DK081559 and NIA AG000029