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A polyphenol‐rich sorghum cereal alters colon microbiota and plasma metabolites in overweight subjects (270.7)
Author(s) -
Seidel Derek,
Martínez Inés,
Taddeo Stella,
Joseph Maria,
Carroll Raymond,
Haub Mark,
Walter Jens,
Turner Nancy
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.270.7
Subject(s) - gut flora , food science , faecalibacterium prausnitzii , sorghum , chemistry , overweight , polyphenol , akkermansia , lactobacillus , obesity , biology , biochemistry , endocrinology , fermentation , agronomy , antioxidant
Diet has the potential to impact gut microbiota and metabolism, with implications for obesity and inflammation. We have shown that polyphenol‐rich sumac sorghum (contains condensed tannins) alters microbial populations and metabolites in rats. The goal of this study was to determine if similar effects occur in overweight subjects predisposed to metabolic syndrome (MS). Subjects (n=24) were randomized in a crossover design with high (100 g/d) and low (50 g/d) intakes (4 wk) of sumac sorghum cereal incorporated in their normal diets. Sumac sorghum induced compositional changes in the fecal microbiota, such as an increase (q=0.076) in anti‐inflammatory Faecalibacterium prausnitzii species. Untargeted metabolomic analysis of plasma revealed reductions in amino acid (AA) metabolites as well as increases in microbially‐derived aromatic AA and polyphenol metabolites. 3‐hydroxyhippurate, a product of chlorogenic acid metabolism shown to be reduced in individuals with impaired glucose tolerance, was increased (q=0.0145) following sumac sorghum consumption. Three gamma‐glutamyl AAs produced by gamma‐glutamyl transferase, a biomarker for MS and cardiovascular risk, were decreased (q<0.05) with the 100 g intake. These data suggest sumac sorghum beneficially modulates gut bacteria and their metabolites, which may contribute to reduced inflammation and improved glucose sensitivity. Grant Funding Source : Supported by United Sorghum Checkoff Program R0002‐11.