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Infliuence of age on the absorption, metabolism an excretion of cocoa flavanols (270.4)
Author(s) -
RodriguezMateos Ana,
CifuentesGomez Tania,
Ottaviani Javier,
Schroeter Hagen,
Heiss Christian,
Spencer Jeremy
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.270.4
Subject(s) - excretion , bioavailability , urine , metabolism , population , food science , chemistry , catabolism , zoology , medicine , biology , biochemistry , pharmacology , environmental health
Accumulating evidence from dietary intervention studies suggest that regular consumption of foods and beverages rich in flavanols may have cardiovascular benefits. However, such biological effects are dependent on the bioavailability of flavanols, and, as such, individual variations in absorption, metabolism and excretion are highly relevant. The aim of this study was to investigate whether or not the absorption, metabolism an excretion of cocoa flavanols is age‐dependent. A 3‐armed randomized, cross‐over intervention study was performed in 40 healthy, caucasian men aged 18‐35 or 65‐80 years old. The subjects received either 5.3 or 10.7 mg CF/Kg body weight (BW); 1 gram of acetaminophen was used as a control to compare differences in metabolism. Plasma and urine samples were collected over 24 hours post‐consumption, and were analysed by HPLC with UV, fluorescence and electrochemical detection. Our data demonstrate that the intra‐ and inter‐individual variability of flavanol absorption is relatively low, and while small differences in the metabolism and catabolism of flavanols were identified as a function of age, in general, flavanols were absorbed, metabolised and excreted in a similar fashion, thus supporting future efforts to establish population‐level cocoa flavanol intake recommendations. Grant Funding Source : FP7 grant of the European Union entitled FLAVIOLA (FP7‐KBBE‐2008‐2B).