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Sugar‐sweetened beverage intake is associated with fatty liver in the Framingham Offspring Study (267.3)
Author(s) -
Ma Jiantao,
Fox Caroloine,
Speliotes Elizabeth,
Hoffmann Udo,
Smith Caren,
Saltzman Edward,
Jacques Paul,
McKeown Nicola
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.267.3
Subject(s) - medicine , fatty liver , added sugar , nonalcoholic fatty liver disease , offspring , framingham heart study , obesity , risk factor , framingham risk score , physiology , environmental health , disease , biology , pregnancy , genetics
Nonalcoholic fatty liver disease (NAFLD) affects 20‐30% of US adults, yet its underlying cause is unknown. Excess intake of sugar‐sweetened beverages (SSB), the largest source of added sugar intake in the American diet, is a potential risk factor for NAFLD. We examined the cross‐sectional association between SSB intake and fatty liver in members of the Framingham Offspring cohort (n=1,061; 57% women; mean age 59 y). Liver fat was measured using CT scan, and fatty liver was defined as a liver to phantom ratio <0.33. Cumulative intakes of SSB and diet soda were estimated from FFQ collected at 3 exam cycles over 7 years. Participants were defined as SSB non‐consumers or consumers (3 categories: 1 drink/mo to <1 drink/wk, 1 drink/wk to < 1 drink/d, and 蠅1 drink/d). Participants were also categorized into 4 groups according to diet soda intake as described above. Covariates examined included age, sex, BMI, smoking status, energy intake, alcohol intake, dietary fiber, total fat, and fruit and vegetable intake. After multivariate adjustment, 14.3% (95%CI: 9.1, 19.5%) of non‐SSB consumers and 26.9% (95%CI: 19.5, 34.2%) of daily SSB consumers had fatty liver, P for trend =0.02. No significant association was observed between diet soda intake and fatty liver. In this study sample, daily SSB consumers had nearly 2 fold higher prevalence of fatty liver compared to non‐SSB consumers. Grant Funding Source : Supoorted by the NIH/NHLIBI's Framingham Heart Study, Boston University School of Medicine, and USDA