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Prenatal vitamin D supplementation and infant vitamin D status in Bangladesh (256.4)
Author(s) -
Perumal Nandita,
Mahmud Abdullah,
Baqui Abdullah,
Roth Daniel
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.256.4
Subject(s) - medicine , vitamin d and neurology , vitamin , vitamin d deficiency , placebo , pregnancy , prenatal care , pediatrics , population , alternative medicine , environmental health , pathology , biology , genetics
We aimed to determine the effect of prenatal vitamin D supplementation on infant vitamin D status in Dhaka, Bangladesh (23°N), where vitamin D supplementation is not routine. Serum 25‐hydroxyvitamin D (25(OH)D) concentration was measured at <1, 2, 4, and 6 months of age among infants born to women randomized to receive vitamin D3 (VD: 35,000 IU/week) or placebo (PL) during the 3rd trimester of pregnancy. Mean 25(OH)D (n=115) was significantly higher among infants born to VD vs PL mothers at <1 month (80 ± 20 nmol/L vs 22 ± 18 nmol/L; P<0.001) and at 2 months of age (52 ± 19 nmol/L vs 40 ± 23 nmol/L; P=0.04), but the groups were similar at 4 months (P=0.41) and 6 months (P=0.27). Among infants of PL mothers (n=55), mean 25(OH)D increased to 78 ± 29 nmol/L by 6 months of age. Measured environmental (e.g. season) and dietary factors did not substantially explain the increase in 25(OH)D with age. In conclusion, high‐dose prenatal 3rd trimester vitamin D supplementation substantially improved infant vitamin D status during the early postnatal period. The age‐related rise in 25(OH)D from birth to 6 months suggested that routine postnatal infant vitamin D supplements may have a limited role in this setting. Grant Funding Source : Supported by the Thrasher Fund and the Department of Paediatrics, Hospital for Sick Children