Premium
Metabolomic profiles of childhood obesity and cardiometabolic risk (248.6)
Author(s) -
Perng Wei,
Gillman Matthew,
Watkins Steve,
Patti MaryElizabeth,
Fleisch Abby,
Oken Emily
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.248.6
Subject(s) - adiponectin , metabolite , leptin , medicine , obesity , endocrinology , childhood obesity , triglyceride , metabolic syndrome , body mass index , insulin resistance , cholesterol , overweight
Objective To identify metabolite patterns associated with childhood obesity, and to examine their relations with cardiometabolic risk biomarkers. Methods We quantified 350 metabolites in serum of 262 children 7‐10 y with an untargeted mass spectrophotometry approach. Using principal component analysis, we characterized 18 metabolite patterns. Next, we compared factor scores for each pattern between obese (BMI 蠅 95 %tile; n = 84) and lean children (BMI < 85 %tile; n = 150) to identify patterns related to obesity. Using multivariable linear regression we examined relations of the metabolite factor scores with ln transformed HOMA‐IR, leptin, adiponectin, triglycerides, CRP, and IL‐6. Results Approximately half (50.6%) of the sample were boys; 58.9% were white. Compared to lean children, obese children had higher factor scores for a branched chain amino acid (BCAA) and an androstene steroid (AS) pattern. After adjustment for age, sex, and race, every 1 unit increment in the BCAA score corresponded to 7% (1%, 14%) higher HOMA‐IR, 15% (6%, 25%) higher leptin, and 31% (14%, 49%) higher CRP. Each unit of the AS score was associated with 4% (1%, 7%) higher triglyceride levels, 7% (2%, 11%) lower adiponectin, and 12% (3%, 20%) higher IL‐6. Conclusions: BCAA and steroid metabolite profiles associated with obesity are also related to established biomarkers of cardiometabolic risk during mid‐childhood. Grant Funding Source : National Institutes of Health