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Effects of maternal obesity on breastmilk composition and infant growth (247.7)
Author(s) -
Panagos Patoula,
Matthan Nirupa,
Sen Sarbattama
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.247.7
Subject(s) - medicine , lactation , obesity , composition (language) , endocrinology , calorie , offspring , lactose , physiology , pregnancy , food science , biology , linguistics , philosophy , genetics
Human and animal studies have suggested that maternal body composition and diet affects breastmilk (BM) composition, but there is no data on the effect of maternal obesity on BM composition. Hypothesis: BM composition of obese (Ob) mothers differs and predisposes their infants to increased adiposity and accelerated infant growth compared to lean control (Lc) mothers. Methods: This was a single center, prospective, case control study. BM was collected between 6 and 10 weeks postpartum from Lc (BMI 18‐25 kg/m 2 ) and Ob (BMI >30 kg/m 2 ) mothers. Results: BM from Ob mothers had increased saturated FA and trans FA and decreased monounsaturated FA and polyunsaturated FA content (p<0.05 by the Mann Whitney U test). FA’s with pro‐inflammatory properties (palmitic, docosatetranoic, and stearidonic acids) were increased, and those with anti‐inflammatory properties (gondoic, erucic, nervonic acids) were decreased, in BM from Ob mothers compared to Lc mothers. Total protein, lactose, fat, and calories of BM did not differ between the two groups. Ob infants were heavier, had a larger head circumference, and increased body fat at birth (p<0.05). This trend continued at two months of age, approaching statistical significance. Data analysis is ongoing; 29/42 samples and subjects have been analyzed. Micronutrient analysis is pending. Conclusions: Maternal obesity confers a pro‐inflammatory in utero and post natal environment which may contribute to the predisposition to obesity throughout the offspring lifespan.