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Diet supplemented with anti‐inflammatory and antioxidant nutrients enhance circulating markers of improved health in aging dogs (246.6)
Author(s) -
Panickar Kiran,
Jackson Matthew,
Gao Xiangming,
Yerramilli Murthy,
Jewell Dennis
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.246.6
Subject(s) - oxidative stress , medicine , antioxidant , inflammation , levocarnitine , lipoic acid , food science , physiology , carnitine , chemistry , biochemistry
Aging is associated with chronic low‐grade inflammation and increased oxidative stress. Such age‐related changes may have adverse effects on general health including associated renal, cardiovascular, neurological and dermatological problems. The effect diet supplemented with ingredients having anti‐inflammatory effects including carrots, spinach, tomato pomace, carnitine, and α‐lipoic acid was tested in older dogs. Animals (n=81) were maintained on control or experimental diet for 6 months. Urine and blood and analysis were conducted prior to administering the diet and at 3 and 6 months. The experimental protocol was reviewed and approved by IACUC. When compared to the control diet there was an increased level of peroxiredoxins and DHA at 6 months but a reduction in prostaglandin E2 was observed in both control and experimental groups. There was a significant reduction in 8‐OH‐DG, a marker of DNA damage, and serum SDMA, a marker of progressive kidney dysfunction, when compared to controls. Markers of muscle and cartilage degradation including 3‐methyl histidine and 4‐hydroxyproline respectively, were lower in the experimental group. Harmful microbial byproducts including p‐cresol sulfate and catechol sulfate were also decreased in the experimental group. These data indicate an important role of diet supplemented with potential antioxidant and anti‐inflammatory nutrients in older animals.