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Discovery of novel enzyme activities and metabolic pathways (227.3)
Author(s) -
Gerlt John
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.227.3
Subject(s) - context (archaeology) , metabolic pathway , computational biology , enzyme , function (biology) , metabolomics , biology , computer science , biochemistry , bioinformatics , genetics , paleontology
The Enzyme Function Initiative (EFI) is a Large‐Scale Collaborative Project (U54GM093342) that is devising strategies and tools to facilitate the discovery of the in vitro activities and in vivo metabolic functions of enzymes discovered in genome projects. This talk will provide examples of how 1) bioinformatic and computational tools can be used to predict novel enzymatic functions and pathways; and 2) enzymology, microbiology, and metabolomics can be used to verify those functions and place them in metabolic context. Supported by NIH U54GM093342.