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Nutritional factors and non‐Hodgkin’s lymphoma survival in an ethnically diverse population: The Multiethnic Cohort Study (136.1)
Author(s) -
Maskarinec Gertraud,
Leo Qi Jie,
Ollberding Nicholas,
Kolonrl Laurence,
Wilkens Lynne,
Le Marchand Loic
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.136.1
Subject(s) - medicine , cohort , hazard ratio , proportional hazards model , body mass index , demography , confounding , cohort study , confidence interval , population , non hodgkin's lymphoma , national death index , obesity , gerontology , environmental health , lymphoma , sociology
With an increasing number of non‐Hodgkin’s lymphoma (NHL) survivors, the possible effect of modifiable health behaviors on prognosis has emerged as a topic of interest. For example, obesity appears to be associated with poorer NHL survival. We examined the association of pre‐diagnostic intake of major food groups assessed by food frequency questionnaire at cohort entry with NHL‐specific survival in the five ethnic groups of the Multiethnic Cohort (MEC). MEC participants free of NHL at cohort entry and diagnosed with NHL during follow‐up (N=1348) were followed through linkages to SEER cancer registries and the National Death Index. Cox proportional hazards regression was applied to estimate hazard ratios (HR) and 95% confidence intervals (CI) for low vs. high intake of meat, fish, vegetables, fruits, dairy, and legumes in relation to NHL‐specific mortality while adjusting for potential confounders including body mass index. The mean age at diagnosis was 70.6 (range 45‐89) years. During 4.3±3.5 years of follow‐up, 679 deaths including 457 NHL‐specific deaths occurred. Consumption of vegetables, fruits, meat, fish, and whole grains was not related to survival, but 蠅1 daily serving of dairy was associated with higher (HR=1.36, 95%CI=1.09‐1.70) and 蠅0.5 daily serving of legumes with lower (HR=0.66, 95%CI=0.49‐0.87) NHL‐specific mortality. Stratification by ethnicity suggested that these associations were limited to Latinos and Whites and not seen in African Americans, Native Hawaiians, and Japanese Americans. Despite the small number of foods associated with survival, the results suggest that diet may influence NHL outcome, possibly through phytanic acids, calcium, or vitamin D in dairy foods and the anti‐inflammatory action of legumes. Grant Funding Source : R37 CA 54281 and P01 CA 33619