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Protective effects of camel’s milk in tri‐nitrobenzensulfonic acid‐induced colitis in rats: modulation of inflammatory cytokines and oxidative stress (134.6)
Author(s) -
Arab Hany,
Salama Samir,
Eid Ahmed,
Omar Hany,
Arafa ElShaimaa,
Maghrabi Ibrahim
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.134.6
Subject(s) - oxidative stress , nitric oxide , colitis , pharmacology , inflammatory bowel disease , medicine , antioxidant , glutathione , myeloperoxidase , inflammation , immunology , chemistry , biochemistry , disease , enzyme
Current treatment strategies for inflammatory bowel diseases (IBD) are associated with several adverse effects, and thus, the search for effective agents with minimal side effects merits attention. Camel’s milk (CM) is endowed with antioxidant/anti‐inflammatory features and has been reported to protect against diabetes and hepatic injury, however, its effects on IBD have not been previously explored. In the current study, we aimed to investigate the potential alleviating effects and the underlying mechanisms of CM against tri‐nitrobenzensulfonic acid‐induced colitis in rats. CM (10 ml/kg b.i.d. by oral gavage) effectively suppressed the severity of colon injury as evidenced by amelioration of macroscopic damage, histopathological alterations, leukocyte influx and myeloperoxidase activity. Administration of CM mitigated the upregulated inflammatory response via inhibition of TNF‐α and IL‐10 cytokines and caspases‐3 as an apoptotic marker. The attenuation of CM to colon injury was also associated with suppression of oxidative stress via reduction of lipid peroxides and nitric oxide along with boosting the antioxidant defenses through restoration of colon glutathione and total anti‐oxidant capacity. Together, our study highlights evidences for the promising alleviating effects of CM in colitis. Thus, CM may be an interesting complementary approach for the management of IBD.