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Skeletal muscle fat accumulation and increased fatty acid saturation are related to worsening glucose control in older adults (133.8)
Author(s) -
Dunville Keagan,
Kim Jung Eun,
Li Junjie,
Conley Travis,
Cheng JiXin,
Talavage Thomas,
Couture Cortni,
Campbell Wayne
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.133.8
Subject(s) - medicine , endocrinology , fatty acid , chemistry , adipose tissue , insulin resistance , saturated fatty acid , insulin , biochemistry
Increased inter‐muscular adipose tissue (IMAT) content and intra‐myocellular lipid (IMCL) fatty acid saturation (FAS) are implicated in insulin resistance (IR), but potential relationships require further investigation because of limited data. This study examined the associations between IMAT content, IMCL FAS, and fasting plasma glucose concentrations in 10 men and women, age range 65‐76 y, plasma glucose 101±11 mg/dL (range 87‐114 mg/dL). Thigh muscle and adipose tissue volumes (magnetic resonance imaging) and the FAS of vastus lateralis IMCL (from muscle biopsies using Coherent Anti‐scattering Raman Spectroscopy and Spontaneous Raman Spectroscopy) were quantified. IMAT volume, standardized with respect to muscle tissue volume (ratio 0.10±0.02), was positively correlated with the ratio of saturated to unsaturated fatty acids in IMCL (r=0.709, p=0.02). IMAT volume and IMCL FAS were both positively associated with plasma glucose concentration (β=300.6, p=0.02, and β=105.4, p=0.02, respectively). These results suggest that inter‐muscular fat accumulation and increased myocellular fatty acid saturation are related to each other and both may contribute to worsening glucose control. Grant Funding Source : Supported by NIH UL1 TR6, Purdue Ingest Behav Res Ctr, Amer Egg Board, Dairy Res Inst