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Maternal upper‐body circumferences predict human milk adiponectin concentration (131.8)
Author(s) -
Minter Anne,
Lee Seung,
Woo Jessica,
Dolan Larry,
Morrow Ardythe,
NommsenRivers Laurie
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.131.8
Subject(s) - adiponectin , medicine , waist , endocrinology , anthropometry , morning , waist–hip ratio , insulin , obesity , insulin resistance
Prenatal measures explain little of human milk adiponectin (HMA) variation. We examined whether postpartum metabolic and fat depot measures predict HMA from milk sampled concurrently. Participants underwent a morning oral glucose tolerance test, anthropometry (hip, iliac crest, waist, and under‐breast circumferences; weight and BMI), and breast expression (N=20). Serum insulin, glucose, and total adiponectin were assayed, and insulin sensitivity and secretion were estimated. HMA was assayed using ELISA. Spearman rank coefficients and linear regression were used to examine relations with HMA. Serum adiponectin was the single significant metabolic correlate with HMA (r=0.45, p=0.048). HMA was not significantly correlated with BMI or weight, but became more negatively correlated with fat‐depot specific anthropometry with increasing proximity to the breast: hip (r=‐0.32, p=0.164); iliac crest (r=‐0.46, p=0.039); waist (r=‐0.50, p=0.025); under breast (r=‐0.56, p=0.011). Combined, serum adiponectin and waist circumference predicted 47% of HMA variation (p=0.002). Thus, upper body fat depots may be an important source of HMA independent of circulating adiponectin levels. Grant Funding Source : NIH 8 ULI TR000077