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Dehydroglyasperin C, one of licorice‐derived prenylflavonoids, had antioxidant and cognitive enhancing properties (124.5)
Author(s) -
Seo Ji Yeon
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.124.5
Subject(s) - morris water navigation task , acetylcholine , hippocampus , antioxidant , chemistry , acetylcholinesterase , cholinergic , pharmacology , oxidative stress , memory impairment , neuroscience , superoxide dismutase , reactive oxygen species , psychology , cognition , medicine , biochemistry , enzyme
Oxidative stress occurs as a result of an imbalance between reactive oxygen species formation and the capacity of antioxidant defenses. The purpose of the present study was to elucidate the antioxidant properties of licorice‐derived prenylflavonoids such as dehydroglyasperin C(DGC), dehydroglyasperin D(DGD) and isoangustone A(IAA). In addition, we investigated the protective effect of DGC from the memory deficits and cognitive function impairment in scopolamine‐induced mice. The learning memory ability of mice was evaluated by passive avoidance test. While the spatial learning and memory abilities of mice were assessed by Y‐maze and Morris water maze tests. We found that DGC improved the cognitive function of mice injected with scopolamine in a dose‐dependent manner. Moreover, DGC recovered the scopolamine‐induced spatial memory deficiency as assessed by Y‐maze test. The inhibitory activity of DGC against acetylcholine esterase present in hippocampus and cerebral cortex extracts was also examined. In conclusion, these results suggest that DGC attenuates scopolamine‐induced memory impairment maybe through enhancement of the cholinergic nervous system via acetylcholine esterase inhibition as well as antioxidative activity. Grant Funding Source : Supported by NRF‐2010‐0027204 and 2011‐0009782 and IPET (High Value‐added Food TechnologyDevelopment Program, 2012, 112066‐3), S. Korea