z-logo
Premium
Zinc supplementation improves outcomes associated with traumatic brain injury but does not overcome risks associated with combined ethanol intake (122.4)
Author(s) -
Morris Deborah,
Levenson Cathy
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.122.4
Subject(s) - traumatic brain injury , binge drinking , anxiety , zinc deficiency (plant disorder) , zinc , elevated plus maze , depression (economics) , medicine , ethanol , anesthesia , poison control , psychology , physiology , psychiatry , injury prevention , micronutrient , pathology , chemistry , biochemistry , emergency medicine , organic chemistry , economics , macroeconomics
In addition to the known behavioral and cognitive impairments, including memory deficits, depression, and anxiety associated with traumatic brain injury (TBI), there is an increased risk for new onset heavy weekly drinking, binge drinking, and alcohol‐related problems. Our previously published work has shown that zinc supplementation robustly reduces behavioral deficits associated with TBI. Our objective was to examine the behavioral and cellular outcomes associated with TBI that are complicated by ethanol consumption, as well as the effect of zinc supplementation on these outcomes. Adult male rats were fed a zinc supplemented (180 ppm) or zinc adequate (30 ppm) diet for 4 weeks followed by a moderately‐severe TBI using controlled cortical impact. After injury, rats were given 3 g/kg of ethanol daily for 7 days via gavage. Ethanol intake exacerbated TBI‐induced anxiety‐like and depression‐like behaviors and significantly impaired the efficacy of zinc supplementation. While ethanol did not worsen learning and memory, ethanol intake prevented zinc supplementation from improving Morris water maze performance. Furthermore, the world’s highest field strength magnet (21.1 Tesla) for in vivo MRI, diffusion mapping, and spectroscopy, is being used to examine the mechanisms by which ethanol prevents the efficacy of zinc after TBI. Grant Funding Source : Supported by U.S. Army MRMC and NIH grant GM081382

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here