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Plasma amino acid concentrations following a beef‐rich lunch meal and the effects on appetite control and satiety in healthy adults (120.1)
Author(s) -
Ortinau Laura,
Lasley Tyler,
Douglas Steve,
Leidy Heather
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.120.1
Subject(s) - appetite , ghrelin , meal , valine , peptide yy , food science , endocrinology , medicine , zoology , chemistry , amino acid , hormone , biology , biochemistry , neuropeptide y receptor , neuropeptide , receptor
Background : The consumption of dietary protein leads to improved appetite and satiety. However, it is unclear as to the actual nutrient signal that elicits these responses. Purpose : To identify the amino acids (AAs) that serve as nutrient signals for appetite and satiety following a beef‐rich lunch meal. Methods : Twenty‐three adults (age 23 ± 1 y; BMI: 23.4 ± 0.6 kg/m 2 ) consumed a 400 kcal beef‐rich lunch meal containing 34 g of protein. Questionnaires and blood samples were collected at baseline and every 60 min thereafter for 180 min. Post‐lunch outcomes included perceived hunger and fullness and plasma ghrelin, GLP‐1, PYY, and AA concentrations. Results : Multivariate regression analyses revealed that post‐lunch plasma AAs concentrations accounted for only 10% of the variability in hunger (p<0.01) and 16% of the variability in fullness (p<0.001). However, post‐lunch plasma AAs concentrations accounted for 57% of the variability in PYY (p<0.001), 69% of the variability in GLP‐1 (p<0.001), and 52% of the variability in ghrelin concentrations (p<0.001). The essential AAs eliciting these effects were threonine, lysine, phenylalanine, and valine. Conclusion : Although plasma AA concentrations following a beef‐rich lunch meal elicit very little effect on perceived sensations, they do exert a substantial effect on the gastro‐intestinal hormones associated with appetite control and satiety in healthy adults. Grant Funding Source : Supported by: The Beef Checkoff