Premium
Modeling fetal heart rate decelerations and partial oxygen pressure changes in response to repeated umbilical cord occlusions (1180.3)
Author(s) -
Najera Chesler Aisha,
Radunskaya Ami,
Frasch Martin
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1180.3
Subject(s) - fetal heart rate , umbilical cord , fetus , medicine , heart rate , cardiology , fetal distress , cord , blood pressure , anesthesia , surgery , pregnancy , anatomy , genetics , biology
Mathematical models can be used to study the complex cardiovascular and metabolic fetal responses during labor and assist with the interpretation of fetal heart rate (FHR) decelerations before the fetus is severely compromised. Our modeling approach was to include blood flow to the heart and brain and incorporate several key features, such as oxygen delivery to the brain, blood flow redistribution, blood pressure, chemo and baro‐receptor mechanisms, all of which affect FHR. Model simulations show a qualitatively good fit with published data (Frasch MG, 2009) on FHR values obtained from studies in near‐term fetal sheep, where mild, moderate and severe cord occlusions are induced. The model is used to examine a broad range of critical incidents, augmenting those observed experimentally. The model can then be used to explore in silico features of the FHR signal that are important in detecting fetal distress during cord occlusions of variable intensity, duration and frequency.