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Pinhão‐manso ( Jatropha curcas ) demonstrates potent antibacterial properties in a rat model of third degree burns (1180.18)
Author(s) -
Paulillo Luis,
Sousa Lessa Gladssinay,
Isaacson Janalee,
Mo ChengLin,
Brotto Leticia,
Abreu Eduardo,
Brotto Marco,
Gomes Mourão e Lima Januario
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1180.18
Subject(s) - jatropha curcas , euphorbiaceae , traditional medicine , jatropha , burn out , biology , botany , medicine , biodiesel , biochemistry , catalysis , clinical psychology
Pinhão‐manso (Jatropha curcas L.; JC) is multipurpose perennial plant native from Brazil that belongs to the Euphorbiaceae family. This plant has mainly been considered for its potential as an alternative source of fuel. We recently demonstrated that JC has very potent protective activity against the toxic effects of ethanol in both tenocytes and muscle cells. Here we employed a rat model of 3rd degree burn to compare the effects of JC with silver sulfadiazine (SS). Microbiological analyses were conducted 1, 7, and 21 days after localized burn was induced. We found that at Day 1, all experimental groups presented with the same type of bacteria in their burns. During the course of these observations it make evident that there was significant reduction of bacterial infection in the group treated with JC as compared with the group treated with SS. The morphological appearance of the burns in JC treated group was also improved as compared to JC. Our new results suggest that JC has anti‐bacterial actions that could be further explored for medicinal use. Grant Funding Source : Supported by Conselho Nacional de Pesquisa (Brazil), CAPES (Brazil) and the Thompson Endowment Fund