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Increased pressure gradient across veins in human limbs induces sympathetic activation (1170.1)
Author(s) -
Cui Jian,
Blaha Cheryl,
Herr Michael,
Muller Matthew,
Drew Rachel,
Sinoway Lawrence
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1170.1
Subject(s) - distension , saline , medicine , blood pressure , reflex , baroreflex , anesthesia , heart rate , sympathetic nervous system , anatomy
We showed that venous distension induced by saline infusion into veins of an arterially occluded arm evokes reflex increases in muscle sympathetic nerve activity (MSNA) and blood pressure (BP). We have also observed that negative pressure on an occluded limb increases MSNA. We speculate that the responses with these two models are evoked through a similar mechanism. To examine this question, BP, heart rate, and MSNA were assessed in 11 young healthy subjects, when 100 mmHg negative pressure was applied on an arterially occluded limb (termed “NPOL”) for 2 min. Limb occlusion without suction was used as a control. In a separate visit, saline (5% arm volume) was infused into veins of the arterially occluded arm. Both NPOL and the saline infusion into the occluded arm significantly increased MSNA and BP. Both MSNA (R=0.643 for arm, R=0.664 for leg) and BP (R=0.786 for arm, R=0.522 for leg) responses during NPOL were significantly correlated with the responses with the saline infusion into the arm. The MSNA and BP responses during saline infusion were not correlated with the responses during limb occlusion. These observations suggest that the mechanisms responsible for sympathetic activation during limb suction are similar to those seen during infusion induced venous distension. Thus, the NPOL model can be employed to study the venous distension reflex. Grant Funding Source : Supported by NIH P01 HL096570 (LIS) and UL1 TR000127 (LIS)