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Effects of dairy vs. sugar‐sweetened products on insulin sensitivity, pancreatic β‐cell function and plasma lipids in men and women at risk for type 2 diabetes mellitus (117.3)
Author(s) -
Maki Kevin,
Nieman Kristin,
Schild Arianne,
Kaden Valerie,
Lawless Andrea,
Kelley Kathleen,
Rains Tia
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.117.3
Subject(s) - medicine , type 2 diabetes , insulin , endocrinology , insulin resistance , meal , type 2 diabetes mellitus , diabetes mellitus , crossover study , insulin sensitivity , sugar , zoology , food science , chemistry , biology , placebo , alternative medicine , pathology
This randomized, controlled, crossover trial assessed the effects of dairy (2 servings/d 2% milk and 1 serving/d low‐fat yogurt) vs. sugar‐sweetened (2 servings/d non‐diet soda and 1 serving/d non‐dairy pudding) product consumption for 3 wk on insulin sensitivity, β‐cell function, and plasma lipids. Subjects were 34 consumers of sugar‐sweetened beverages (蠅2 servings/d), 50% female, mean age 53.8 y and BMI 32.2 kg/m 2 , with multiple risk factors for type 2 diabetes mellitus (T2DM). A liquid meal tolerance test (LMTT) was administered at baseline (BL) and the end of each treatment. Changes from BL (dairy condition shown first) were significantly different between conditions for mean homeostasis model assessment insulin sensitivity (HOMA‐%S; 17.8 vs. ‐17.3%; P = 0.01; BL = 127.1%), LMTT disposition index (‐0.03 vs. ‐0.36; P = 0.01; BL = 2.59), and HDL‐C (0.8 vs. ‐4.2%; P = 0.01; BL = 44.3 mg/dL). Median changes from BL in LMTT Matsuda insulin sensitivity index (0.54 vs. ‐0.26; BL = 4.16) and HOMA β‐cell function (0.5 vs. 3.8%; BL = 68.4%) did not differ significantly between treatments. These results suggest that dairy consumption, compared with sugar‐sweetened products, improves HOMA‐%S, LMTT disposition index, and HDL‐C in men and women at‐risk for T2DM. Grant Funding Source : Dairy Research Institute