Premium
Effects of a 6‐month trial of weight‐loss diet plus aerobic exercise versus matched (by dose/intensity) exercise alone on glucose tolerance and insulin resistance in subjects with pre‐diabetes (117.2)
Author(s) -
Bales Connie,
Starr Kathryn,
Granville Esther,
Slentz Cris,
Bateman Lori,
Willis Leslie,
Piner Lucy,
Kraus William
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.117.2
Subject(s) - prediabetes , medicine , insulin resistance , weight loss , aerobic exercise , endocrinology , impaired fasting glucose , diabetes mellitus , population , impaired glucose tolerance , insulin , type 2 diabetes , obesity , environmental health
The Diabetes Prevention Program first demonstrated benefits of lifestyle interventions for delaying progression of pre‐diabetes. Our study examines the separate effects of a weight‐loss diet plus exercise or exercise alone on oral glucose tolerance (OGTT) in a randomized 6‐mo. study of participants (age=57.8 + 7.6 y; BMI 30.6±2.9) with pre‐diabetes (fasting glucose 95‐124 mg/dL). Weight reduction diet + moderate aerobic exercise (D+Ex; n=41) was compared to a matched exercise program with no diet component (Ex; n=36). Baseline age, BMI, fitness level, and gender/race did not differ. D+Ex included a weekly support group and body weights (BW). Compliance with supervised exercise was similar for D+Ex and Ex (87.8% and 84.2%). At 6 mo., BW reductions in D+Ex (‐6.1 + 5.0 kg) exceeded (p<0.0001) those in Ex (‐0.9±3.3 kg). D+Ex improved (p<0.0001) fasting glucose (‐4.9±8.1 mg/dL), fasting insulin (‐3.5±3.8 mg/dL), 2‐hr glucose (‐20.5±35.9 mg/dL), HOMA‐IR (‐1.0±1.2) and glucose areas under the response curve. Ex, as well as D+Ex, improved (p<0.05) 2‐hr glucose, insulin area under the curve, and Matsuda Index. Weight loss plus exercise was superior for improving glucose tolerance/insulin resistance in this population. Thus, clinical recommendations for prediabetes should emphasize diet‐induced weight loss, along with exercise, as the first line of treatment.Grant Funding Source : Supported by NIDDK R01‐DK081559 and NIA AG000029.