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Progressive vasoconstrictory sympathetic outflow via muscle metaboreflex activation gradually increases human arterial stiffness (1165.4)
Author(s) -
Prodel Eliza,
Fernandes Igor,
Barbosa Thales,
Hawerroth Pedro,
Nobrega Antonio Claudio,
Vianna Lauro
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1165.4
Subject(s) - arterial stiffness , cardiology , medicine , heart rate , mean arterial pressure , blood pressure , contraction (grammar) , artery
Previous studies demonstrated that stepped intravenous infusion of noradrenaline increases aortic and peripheral arterial stiffness. However it is unknown whether these findings could be extended to physiological stimulation. Given this, we tested the hypothesis that a graded vasoconstrictory sympathetic outflow via skeletal muscle metaboreflex activation would gradually increase human aortic arterial stiffness (AIx). In nine healthy male subjects (22±2 yr), the graded isolation of the muscle metaboreflex was achieved by post‐exercise ischemia (PEI) following moderate and high intensity static handgrip performed at 30% and 40% maximum voluntary contraction, in a counterbalanced order. Heart rate (ECG), mean arterial pressure (MAP), Alx (SphygmoCor) and radial artery diameter (Doppler) were measured. MAP increased significantly from rest during PEI30% (105±4 mmHg vs 83±2 mmHg; P<0.05) and was a further augmented during PEI40% (115±3 mmHg vs PEI30%; P<0.05), indicating graded metaboreflex activation. Similarly, Alx increased significantly from rest during PEI30% (Rest ‐9±3% vs PEI30% 9±5%, P<0.05) and was further augmented during PEI40% (17±4% vs PEI30%; P<0.05). Radial artery diameter was unchanged throughout. The present results extend previous findings from pharmacological studies by showing that progressive muscle metaboreflex activation gradually increases human arterial stiffness. Grant Funding Source : Supported by CAPES, CNPq, FAPERJ, FINEP