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Regulation of the browning of human white adipose: evidence for sympathetic control and sexual dimorphic responses to sprint interval training (1160.4)
Author(s) -
Scalzo Rebecca,
Peltonen Garrett,
Giordano Gregory,
Binns Scott,
Klochak Anna,
Paris Hunter,
Schweder Melani,
Szallar Steve,
Wood Lacey,
Larson Dennis,
Luckasen Gary,
Hickey Matthew,
Bell Christopher
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1160.4
Subject(s) - medicine , endocrinology , fgf21 , fndc5 , white adipose tissue , adipose tissue , skeletal muscle , sympathetic nervous system , biology , fibronectin , fibroblast growth factor , receptor , blood pressure , extracellular matrix , microbiology and biotechnology
The conversion of white to thermogenic beige adipose tissue has been proposed as an obesity treatment. 3 regulators of this conversion have emerged but information regarding their control is limited. We present 2 studies examining control of these regulators. Study 1: In 10 men, plasma irisin and fibroblast growth factor 21 (FGF21) concentrations were determined prior‐to/during sympathetic activation via hypoxic gas breathing (FIO 2 =0.11). The measurements were performed twice: with and without sympathetic inhibition (clonidine). FGF21 was unaffected by basal sympathetic inhibition (338±113 vs . 295±80 pg/mL; P =0.43; mean±SE), but was increased during sympathetic activation (368±135); clonidine abrogated this response (269±93; P =0.035). Irisin was unaffected by sympathetic inhibition and/or hypoxia ( P >0.21). Study 2: Plasma irisin and FGF21 concentrations, and skeletal muscle protein content of fibronectin type III domain containing 5 ( FNDC5) was determined in 19 adults pre/post 3 weeks of sprint interval training (SIT). SIT decreased FGF21 (338±78 vs . 251±36; P =0.046) but did not affect FNDC5 ( P =0.79). Irisin was decreased in males (127±18 vs . 90±23 ng/mL; P =0.045) and increased in females (139±14 vs . 170±18). These data suggest a regulatory role of acute sympathetic activation pertaining to the browning of white adipose; further, there appears to be a sexual dimorphic response of irisin to SIT. Grant Funding Source : Supported by DARPA: N66001‐10‐c‐2134