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Endothelial‐dependent dilation is lower in males compared to females on a controlled sodium diet (1156.6)
Author(s) -
LenEdwards Shan,
Matthews Evan,
Ramick Meghan,
Brian Michael,
Edwards David,
Farquhar William
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1156.6
Subject(s) - sodium , blood pressure , brachial artery , dietary sodium , medicine , endocrinology , excretion , lower blood pressure , zoology , chemistry , biology , organic chemistry
Excess dietary sodium has been linked to the development of high blood pressure (BP) and other cardiovascular diseases (CVD) and recently shown to effect endothelial function independently of BP. However, it is unknown whether sodium consumption impacts endothelial function differently in males (M) and females (F). Given the varying habitual intake of sodium, we sought to fix sodium using a controlled diet study. Therefore, the aim of this study was to test the hypothesis that endothelial‐dependent dilation (EDD) would be lower in M as compared to F on a controlled sodium diet set at the recommended intake for Americans. 16 M (29±2 y; BMI 23.8±0.7 kg/m2) and 12 F (31±3 y; 24.3±0.7 kg/m2) completed the study. All subjects were apparently healthy and free of CVD. Subjects consumed a eucaloric diet providing 100 mmol/d of sodium for 7 days. On day 7 of the diet, 24‐hr mean arterial pressure (MAP) was recorded, and blood and urine were collected. EDD was assessed by brachial artery flow‐mediated dilation. Urinary sodium excretion was not different between M and F (81.4±7.7 vs. 93.9±22.8 mmol/24hr, p > 0.05) while 24‐hr MAP was higher in M (88±1 vs. 82±1.3; p<0.05). EDD was significantly lower in M than F (7.0±0.8% vs. 10.4±1.2%; p < 0.05). These data demonstrate that M have a lower EDD than F at the recommended intake of sodium. Future research should focus on exploring the mechanisms underlying this difference. Grant Funding Source : Supported by R01 HL 104106