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Effect of inhibiting the synthesis of Ang II in a model of preeclampsia (1140.5)
Author(s) -
Rosas Paula,
Tufiño Cecilia,
Bobadilla Rosa
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1140.5
Subject(s) - captopril , preeclampsia , phenylephrine , pregnancy , medicine , endocrinology , renin–angiotensin system , pathophysiology , aorta , angiotensin ii , biology , blood pressure , genetics
The renin angiotensin system (RAS) plays an important role in the physiological adaptations of pregnancy, so that alterations in the functioning of this system may contribute to the development of hypertensive disease of pregnancy or preeclampsia. The aim of this study was to determine the contribution of the RAS in a model of preeclampsia. To meet the objective was reduced uterine circulation during pregnancy with coarctation of the aorta at the level subrenal in Wistar rats aged 2 months. Captopril was administered (5mg/kg vo) for 1, 2 or 3 weeks. Joined weight, glucose and PA. There were concentration‐response curves to angiotensin II and phenylephrine (Fen) in isolated aortic rings using a conventional preparation of isolated. The results show that the model alters glucose concentrations and that the tx with captopril (2 to 3 weeks) and reduces the increase in PA, while a significant increase in the vascular response to tx Fen with captopril (3 weeks). These results allow us to conclude that the RAS is involved in both vascular response as metabolic alterations related to the pathophysiology of preeclampsia pregnancy from the start.