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Oral cavity morphometric evaluation in 7,12 dimethylantracene administration (1139.11)
Author(s) -
Cabeças José Ricardo,
Costa Eduardo,
Alves Gonçalo,
Jesus Patrícia,
Cabrita António
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1139.11
Subject(s) - dmba , xenobiotic , physiology , carcinogen , benzanthracene , medicine , pharmacology , chemistry , biology , cancer , carcinogenesis , biochemistry , enzyme
Many injuries which occur in human body is mainly caused by the action of xenobiotics present in the environment and coming into contact with the body.舲 The xenobiotics they induce a good morphological identifiable damage, also cause functional alterations of varying severity. The action of xenobiotics on the body depends on many factors among which we highlight: the chemical nature of the molecule, its concentration in the environment, the repeated contact, the gate of entry and the physiological activity of the organism. DMBA is a toxic present in the contaminated environment, in some foods and also in tobacco smoke 7. The aim of this work is to evaluate the influence of DMBA in morphological changes of the periodontal ligament.舲 In this study was used 20 male Wistar rats with eight weeks old at the beginning of the study. The rats were distributed into two groups of 10 animals each. Group I, the control group, was maintained for 8 weeks without any inducing manipulation changes. Group II was subjected to the administration of 7,12‐dimethyl‐benzanthracene (DMBA) three times a week, for 4 weeks at a dose of 20 mg / kg in each takes.舲 At the end of the administration's, the animals were sacrificed and their necropsy was made. In group I, the value of R1 was 0.07 ± 0.07 and R2 was 0.79 ± 0.25, not checking the presence of DMBA in adipocytes. The distribution of R2 values in this group was as follows: 15.38% small, 69.23% medium,10.99% large and 3.30% very large. In group II, the value of R1 was 0.07 ± 0.04 and R2 was 0.84 ± 0.35. The distribution of R2 values in this group was as follows: 15.07% small, 63.01% medium, 8.22% large and 12.33% very large. The animals in this group was detected the presence of DMBA in adipose tissue at all. DMBA in the studied conditions does not significantly interfere with the periodontal ligament in morphological terms.