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Prenatal steroid exposure promotes expression of renal injury indices in African American females (1134.11)
Author(s) -
Gwathmey TanYa,
Chappell Mark,
Nixon Patricia,
Washburn Lisa
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1134.11
Subject(s) - creatinine , endocrinology , medicine , renal function , kidney disease , offspring , urinary system , nephrotoxicity , kidney , gestation , cohort , pregnancy , biology , genetics
Administration of steroids to expectant mothers at risk for pre‐term delivery is standard practice, but may have detrimental effects on kidney development and function in the offspring. African‐Americans (AA) experience higher rates of both pre‐term birth and kidney disease than other racial and ethnic groups, and the onset of kidney disease occurs much earlier in life for AA. This study examined the expression of specific markers of renal injury in a cohort of AA females (age 14) either born prematurely (<32weeks gestation) and exposed in utero to betamethasone (BMX; N=12), born prematurely but not exposed (PRE; N=18) or born at term (>37 weeks; N=12). In comparison to term AA, the oxidative stress marker 8‐Isoprostane tended to be higher in PRE [10.9 + 1.0 vs. 8.9 + 1.9 pg/g creatinine; P = 0.06], but was higher in the BMX cohort [13.1 + 1.6 pg/g creatinine; P < 0.05]. Angiotensinogen excretion, a biomarker for glomerular damage and precursor to the fibrotic and inflammatory peptide angiotensin II, did not differ between BMX and PRE [0.14 + 0.04 vs. 0.12 + 0.04 ng/g creatinine], but was higher than in term subjects [0.06 + 0.01 ng/g creatinine; P<0.05]. While urinary angiotensin II tended to be higher in BMX [0.20 + 0.09 pg/g creatinine], no significant differences were observed between groups [PRE: 0.07 + 0.01 vs. Term: 0.11 + 0.06 pg/ g creatinine]. The microalbumin/creatinine ratio was higher in PRE [0.25 + 0.18 mg/g] and BMX [0.25 + 0.13 mg/g] as compared to term [0.04 + 0.01 mg/g]. In summary, we show that pre‐term birth is associated with increased expression of urinary 8‐Isoprostane, angiotensinogen and microalbumin, and is exacerbated by prenatal exposure to betamethasone. These findings suggest preterm birth and the accompanying prenatal steroid exposure may result in an increased susceptibility to renal injury and that indices of damage can be detected early during adolescence. Grant Funding Source : Supported by AHA 12CRP9390000 and HD047584