Premium
Hypertension impairs spontaneous baroreflex heart rate control during exercise and muscle metaboreflex activation (1132.9)
Author(s) -
Augustyniak Robert,
Spranger Marty,
AbuHamdah Rania,
Kaur Jasdeep,
Hammond Robert,
SalaMercado Javier,
Ichinose Masashi,
O'Leary Donal
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1132.9
Subject(s) - baroreflex , medicine , heart rate , cardiology , blood pressure , rest (music) , anesthesia
Spontaneous baroreflex sensitivity (SBRS) in the control of heart rate (HR) is reduced in proportion to exercise intensity and magnitude of MMA. In hypertension (HTN), while SBRS is reduced at rest, the effect of exercise and MMA are unknown. In eight conscious dogs we measured SBRS in the control of HR (sequence method) at rest, during mild dynamic exercise, and during MMA (via imposed reductions of hindlimb blood flow), in the same animals before and 38±7 days after induction of HTN (via unilateral partial renal artery occlusion). HTN increased resting mean arterial blood pressure from 94±3 to 142±14 mmHg. In control, with the transition from rest to exercise, SBRS decreased from ‐4.01±0.77 to ‐2.38±0.61 bpm/mmHg and reduced further to ‐1.78±0.43 with MMA. In HTN, SBRS was significantly reduced at rest (‐2.38±0.34), during exercise (‐1.05±0.12) and MMA (‐0.90±0.14).We conclude that in HTN SBRS in the control of HR is impaired to similar degrees at rest, during exercise and MMA. Grant Funding Source : HL‐55743 and HL‐095819