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Measurements of the stomachs and duodenums of fasted and sated rats (1110.2)
Author(s) -
Lorber Mortimer
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1110.2
Subject(s) - duodenum , stomach , anatomy , chemistry , medicine
Rats feed until sated. Thus, gastric and duodenal dimensions likely increase. Under Na pentobarbital the stomach and proximal duodenum were exposed via a midline incision. Measurements were made by a calipers and digital micrometer. Eight fasted adult females and eight which ate chow until sated, as judged by pausing or preparation for sleep, were studied. They ate (mean + s.d.) 4.74 + 1.17 g of chow. Body weights and visceral dimensions were compared by unpaired t‐tests. A P value < 0.05 was deemed significant. The fasted:sated mean + 1 s.d. values were: Body Weight (g) 186 + 9:195 + 10 (ns). Gastric values (cm): Width 1.94 + 0.13: 3.86 + 0.53; Rostrocaudal Height 1.78 + 0.15: 2.84 + 0.30; Dorsoventral Thickness 0.73 + 0.16: 1.70 + 0.25. (P < 0.001 for all). Proximal duodenal values (cm) were: Rostrocaudal Height 0.53 + 0.09: 0.55 + 0.17 (ns); Dorsoventral Thickness could not be obtained because the proximal duodenum is bound to the peritoneum. Separation would be unphysiological. All fasted rats but one had dorsoventrally concave duodenums. All sated rats but one had flat duodenums, suggesting some gastric emptying had occurred. The ratios of mean sated:fasted dimensions were 1.99 for Width, 1.60 for Height, and 2.33 for Thickness. Thus, the stomach markedly thickens. Its height increases least and its width, which doubles, is intermediate. In achieving satiety the rat stomach enlarges both significantly and anisotropically. , Grant Funding Source : Personal