Premium
Chronic blockade of the renin‐angiotensin system improves glucose metabolism and pancreatic superoxide dismutase activity in insulin resistant rats (1108.12)
Author(s) -
Rodriguez Ruben,
Minas Jacqui,
VazquezMedina Jose,
Nakano Daisuke,
Nishiyama Akira,
Ortiz Rudy
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1108.12
Subject(s) - medicine , endocrinology , insulin resistance , insulin , blockade , superoxide dismutase , diabetes mellitus , carbohydrate metabolism , oxidative stress , receptor
Blockade of the renin‐angiotensin‐system (RAS) improves pancreatic function, decreases fasting blood glucose (FBG), glucose intolerance, insulin resistance (IR) and delays the onset of type 2 diabetes. However, the timing of the onset of the beneficial effects of RAS blockade is not clear. To assess the timing of the beneficial effects of RAS blockade, we measured fasting blood glucose, glucose intolerance, insulin resistance index (IRI) and pancreatic antioxidant activity after 2 and 11 weeks of angiotensin receptor blocker (ARB) treatment in the following groups of rats: 1) LETO (lean strain‐control), 2) untreated fatty obese‐OLETF, 3) OLETF + ARB (ARB; 10 mg olmesartan/kg/d). OLETF rats exhibited elevated FBG, glucose intolerance and IRI at 9 weeks of age compared to LETO and they worsen with age. Two week treatment with ARB did not decrease FBG, glucose intolerance or IRI, whereas 11 week treatment decreased them by 23%, 26% and 47%, respectively, compared to OLETF. OLETF rats also exhibited decreased pancreatic antioxidant enzyme activity as compared to LETO. Two week treatment with ARB did not increase antioxidant enzyme activity; however, 11 week‐treatment increased 42% superoxide dismutase activity compared to OLETF. These data suggest that the beneficial effects that RAS blockade have on glucose metabolism and pancreatic antioxidant activity are not immediate, but improve with treatment duration. Grant Funding Source : Supported by NIH NCMHD 9T37MD001480.