Premium
Total sleep deprivation and pain perception during cold noxious stimuli in humans: role of sex (1106.8)
Author(s) -
Larson Robert,
Yang Huan,
Durocher John,
Carter Jason
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1106.8
Subject(s) - cold pressor test , medicine , sleep deprivation , noxious stimulus , heart rate , crossover study , threshold of pain , pain perception , sleep (system call) , chronic pain , blood pressure , anesthesia , audiology , nociception , circadian rhythm , physical therapy , placebo , receptor , alternative medicine , pathology , computer science , operating system
Several studies indicate a higher incidence of chronic pain in women compared to men, and that women report higher perceived pain (PP) responses to acute experimentally induced noxious stimuli. To date, studies examining the relations between sleep deprivation and pain have focused on pain threshold methodologies, not sustained noxious stimuli, and potential sex differences have not been explored. Therefore, we hypothesized that 24‐hour total sleep deprivation (TSD) would augment PP during the cold pressor test (CPT), and that women would report higher PP than men. Mean arterial pressure (MAP), heart rate (HR), and PP responses to CPT were recorded in 27 subjects (14 men, 13 women; age 22±1 yrs) after a normal night of sleep (NS) and TSD (randomized, crossover design). PP (Δ6.9±0.5 vs. Δ8.3±0.5 a.u., p<0.01) and HR (Δ9±1 vs. Δ12±1 beats/min, p<0.04) responses to CPT were augmented by TSD. MAP responses to CPT were similar in both conditions (Δ12±1 vs. Δ13±1 mmHg, p=0.57). Contrary to our hypothesis, there were no sex differences in the PP response or cardiovascular reactivity to CPT. Interestingly, changes in MAP were significantly correlated to changes in PP in women, but not men, during both NS and TSD trials (r 蠅 0.67, p 蠄 0.02). In conclusion, TSD augments PP and HR responses to CPT; however, these responses were similar between sexes. Moreover, PP and MAP responses to CPT demonstrated an association in women, but not men.