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The endothelial responses to low‐ and high‐intensity cycling with diesel exhaust exposure (1106.21)
Author(s) -
Giles Luisa,
Richard Normand,
Ruan Jian,
Tebbutt Scott,
Carlsten Christopher,
Koehle Michael
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1106.21
Subject(s) - cycling , medicine , exercise intensity , endothelium , nitrite , cardiology , zoology , chemistry , nitrate , heart rate , blood pressure , biology , archaeology , history , organic chemistry
Outdoor exercisers are frequently exposed to air pollution. How the endothelium responds to exercise in air pollution, and how these responses change with exercise intensity is unknown. The purpose of this study was to determine the endothelial responses to low‐ and high‐intensity cycling with diesel exhaust (DE) exposure. Eighteen males aged 24.56.2 yrs performed 30‐minute trials of low (30% of power at VO 2peak ) and high‐intensity (60% of power at VO 2peak ) cycling, and rest. For each subject, each trial was performed once breathing filtered air (FA) and once breathing DE (300ug/m 3 of PM 2.5 ) for a total of six trials, each separated by 7‐days. Prior to, immediately following, and 1 hour, and 2 hours post‐exposure flow‐mediated dilation (FMD), plasma nitrite/nitrate (NOx), intercellular adhesion molecule (ICAM)‐1, and vascular cell adhesion molecule (VCAM)‐1 were measured. Data were analyzed using repeated‐measures ANOVA. There were no main or interaction effects for FMD. DE exposure did not affect plasma VCAM‐1. Compared to the FA exposure, DE led to lower ICAM‐1 levels following high‐intensity exercise (p<0.05), while plasma NOx was increased (p<0.05). DE exposure does not differentially affect FMD post‐exercise, yet there are significant differences in key biomarkers that warrant further investigation. Grant Funding Source : Supported by: CASEM, Health Canada, the Fraser Basin Council, NSERC