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Aspirin ingestion does not alter the onset or slope of local sweat rate during whole‐body passive heat stress (1104.12)
Author(s) -
Carter Stephen J.,
Herron Robert L.,
Akers S. Zeb,
Collins Ann B.,
Wingo Jonathan E.
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1104.12
Subject(s) - sweat , aspirin , medicine , supine position , ingestion , heart rate , thermoregulation , anesthesia , zoology , surgery , blood pressure , biology
Aspirin ingestion does not alter the onset or slope of local sweat rate during whole‐body passive heat stress Stephen J. Carter , Robert L. Herron, S. Zeb Akers, Ann B. Collins, Jonathan E. Wingo. Department of Kinesiology, The University of Alabama, Tuscaloosa, AL 35487 Aspirin (acetylsalicylic acid; ASA) is a commonly prescribed over‐the‐counter drug. As a fever suppressant ASA may interfere with normal hypothalamic‐mediated temperature regulation. We sought to determine if varying doses of ASA would alter the onset and slope (i.e., sensitivity) of local sweat rate during whole‐body passive heating. Seven healthy men (mean ± SD; 28 ± 3 y) completed a counter‐balanced design to compare ASA treatments (single dose of non‐enteric coated 325‐mg ASA vs. 4 days of 81‐mg ASA) to a control trial. A 10 day washout period was given between ASA treatments. Participants were physically active, free from cardiovascular disease and refrained from vigorous physical activity 24 h prior to testing. Upon arrival, participants were outfitted with a heart rate monitor, rectal thermocouple, 6 skin thermocouples, and a ventilated capsule placed on the dorsal forearm to measure local sweat rate via capacitance hygrometry. To raise mean body temperature (Tb) participants rested supine while hot water (~49 °C) circulated through a tube‐lined suit. Body heating ensued until participants reached a 1.0 °C increase above baseline Tb. ASA did not affect Tb at baseline (P=0.14). The onset and slopes were unaffected by ASA use (P=0.33 and P=0.87, respectively). Additionally, ASA treatments did not alter peak sweat output (P=0.87). Aspirin ingestion did not appear to affect sweat responses in this cohort of men.