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Role of body composition and circulating hormones on resting energy expenditure in obese pregnant women (1101.9)
Author(s) -
PerezRodriguez Marcela,
Haene Jessica,
Castañeda Diana,
Stotland Naomi,
Murphy Elizabeth,
Talavera Juan,
Havel Peter,
King Janet
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1101.9
Subject(s) - medicine , resting energy expenditure , endocrinology , leptin , prolactin , pregnancy , gestation , obesity , hormone , adiponectin , insulin resistance , body weight , biology , genetics
The extra energy required for synthesis and maintenance of new tissue increases the REE during pregnancy. The net change may vary 8‐fold with higher increases seen in obese than non‐obese women. Our objective was to identify body composition and hormonal factors influencing the REE of obese women during the last half of pregnancy. A total of 64 women with BMI >25 kg/m2 , 18‐42 years of age, and no history of chronic disease were recruited at 20 weeks gestation. Three were eliminated due to extreme obesity (BMI=53 kg/m2) and 2 for missing values giving a total of 59 participants. REE, body composition, and insulin resistance (HOMA‐IR), prolactin, progesterone, estradiol, leptin, adiponectin, and IGF‐1 were measured at 20, 28, and 34 weeks gestation. During the 14‐wk study, the REE increase averaged 200 kcal/d. The change varied from a 400 kcal/d decrease to a 590 kcal/d increase. Multivariant models predicted 62% of the variability in REE at 20 weeks, 41% at 28 and 34 weeks, and 24% of the change in REE from 20 to 34 weeks. Significant determinants varied with time of pregnancy: FM, FFM, progesterone and prolactin at 20 wks; FM and FFM at 28 wks; FM, FFM, and IGF‐1 at 34 wks; and FFM and IGF‐1 change predicted the REE change from 20 to 34 wks. Body composition and metabolic hormones only explained 24 to 60% of the REE variability in obese pregnant women suggesting that other factors play a role. Grant Funding Source : NIH Grant R01HD46741.