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Differential effects of neonatal sustained hypoxia exposure on the acute hypoxic ventilatory response among different rat strains (1092.12)
Author(s) -
Warren Philippa,
Bozek Danielle,
Mayer Catherine,
Alilain Warren,
MacFarlane Peter
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1092.12
Subject(s) - hypoxic ventilatory response , hypoxia (environmental) , respiratory system , plethysmograph , medicine , acute exposure , respiration , endocrinology , anesthesia , physiology , chemistry , oxygen , anatomy , organic chemistry
Sustained hypoxia (SH) exposure during a vulnerable period of neonatal development (~11‐15 days of postnatal (P) age) attenuates the acute hypoxic (HVR) ventilatory response in rats. In the current study, we investigated whether the effects of SH exposure on the acute HVR varies among different rat strains. Sprague‐dawley (SD), Fisher (F), and Spontaneously Hypertensive (SHR) rats were exposed to SH (11% O 2 , 5 days) starting at P11. The acute HVR and Dejours test were assessed using whole‐body plethysmography the day after (P16) SH exposure ended. SH abolished the HVR in SHR, but not SD or F rats compared to normoxia raised animals. The transient ventilatory depression following brief (5 minutes) 100% O 2 exposure (Dejours test) was also absent in SHR rats following SH treatment. These data indicate a strain difference in the vulnerability of the respiratory system to neonatal SH exposure; possible genetic determinants for this phenomenon requires further study.