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Augmented pulmonary artery pressure response during exercise in adults born extremely preterm, but not in those with bronchopulmonary dysplasia (1089.4)
Author(s) -
Laurie Steven,
Elliott Jonathan,
Beasley Kara,
Mangum Tyler,
Goodman Randall,
Gladstone Igor,
Lovering Andrew
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1089.4
Subject(s) - bronchopulmonary dysplasia , medicine , cardiology , pulmonary artery , blood pressure , pulmonary hypertension , gestation , physical therapy , gestational age , pregnancy , genetics , biology
Advances in perinatal care in the post surfactant era have increased survivability of infants born extremely preterm (<32 weeks gestation), yet long‐term cardiopulmonary consequences of prematurity in adulthood remain largely unexplored. We studied adults who developed new bronchopulmonary dysplasia (BPD, 22.7 yrs), preterm subjects who did not develop BPD (PRE, 21.1 yrs), and fullterm controls (CONT, 22.7 yrs) at rest and during cycle ergometer exercise in the forward leaning aerobar position. Subjects exercised for 3 min at 25%, 50% and 75% of their maximum workload attained at VO2max from a separate visit. We measured metabolic rate, and pulmonary artery systolic pressure (PASP) with ultrasonography, at rest and during exercise. There were no differences in PASP between the groups at rest. At 50% and 75% VO2max, PASP was higher in PRE subjects than in BPD and CONT subjects, which were not significantly different from each other at any exercise intensity. The slope of the PASP to VO2 relationship was significantly greater in PRE subjects compared to BPD and CONT. These data suggest PRE subjects have a reduced ability for the pulmonary vasculature to accommodate increases in cardiac output during exercise compared to CONT and BPD subjects. Further research is needed to determine if this augmented pressure response during exercise may predispose PRE subjects to developing pulmonary arterial hypertension. Grant Funding Source : Supported by: AHA Scientist Development Grant