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Histone modification and exchange during gene transcription: signals and mechanisms (108.1)
Author(s) -
Workman Jerry,
Venkatesh Swaminathan,
Smolle Mihaela
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.108.1
Subject(s) - chromatin , histone code , histone , histone methylation , histone modifying enzymes , biology , histone h2a , histone h1 , transcription (linguistics) , genetics , microbiology and biotechnology , gene , nucleosome , dna methylation , gene expression , linguistics , philosophy
Maintenance of ordered chromatin structure over the body of genes is vital for the regulation of transcription. Increased access to the underlying DNA sequence results in the recruitment of RNA polymerase II to inappropriate, promoter‐like sites within genes, resulting in unfettered transcription. Our recent studies show how Set2‐mediated methylation of histone H3 on Lys36 (H3K36me) maintains chromatin structure by limiting histone dynamics over gene bodies, either by recruiting chromatin remodelers that preserve ordered nucleosomal distribution or by lowering the binding affinity of histone chaperones for histones, preventing their removal.