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Comparative assay of oxidative stress biomarkers on normotensive and hypertensive, pre‐menopausal and postmenopausal women: a pilot study (1074.8)
Author(s) -
CalzadaFrías Jesús,
LugoMartínez Gabriela,
JiménezZamarripa Carlos,
OcharánHernandez María,
CariñoCortés Raquel,
CalzadaMendoza Claudia
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1074.8
Subject(s) - medicine , oxidative stress , menopause , anthropometry , body mass index , postmenopausal women , physiology , endocrinology , estrogen , antioxidant , biochemistry , chemistry
Menopause is defined as the cessation of menstruation for one year in raw, due to ovarian dysfunction, which decreases the production of estrogen. During this stage, several pathologies can be developed, such as hypertension which is associated to oxidative stress, then, there are two risk factors to participate on cardiovascular diseases. Currently, knowledge of factor present in postmenopause in relationship to cardiovascular diseases can help to propose therapeutic guides to reduce them. Objective: To analyze the association between oxidative stress on pre‐menopausal and postmenopausal women with hypertension. Methods: In the present study were included fifty six divided in four groups: a) normotensive‐premenopausal, b) hypertensive‐premenopausal, c) normotensive‐postmenopausal and d) hypertensive‐postmenopausal. Menopause was corroborated by clinical evaluation. On the other hand, oxidative stress biomarkers analyzed, were a) malondyaldehyde (MDA) for lipid oxidation, carbonyl group for protein oxidation and antioxidant defense was evaluated by determination of carbonyl and sulfhydryl group, respectively; anthropometric evaluation was evaluated too. Results: Women included were classified according to their status (normotensive or hypertensive, pre‐menopausal or postmenopausal) which was corroborated by medical history. The MDA concentration was lower in normotensive premenopausal; with respect protein damage, all groups presented similar levels, finally, postmenopausal women had lower antioxidant defense. On the other hand, in anthropometry evaluation, only body mass index was (BMI) higher in hypertensive‐premenopausal than on the other groups, while in determinations such as wais‐hip ratio, systolic and dyastolic blood pressures, were similar. Conclusion: Oxidative stress is increased in hypertensive postmenopausal women and BMI is related to high blood pressure in in hypertensive‐premenopausal women.