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Caffeine protects cerebral artery function in the reduced uterine perfusion pressure model of preeclampsia (1070.9)
Author(s) -
Dennis Spencer,
Balser Brittany,
Powers Robert,
Novak Jacqueline,
Ramirez Rolando
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1070.9
Subject(s) - caffeine , preeclampsia , medicine , perfusion , blood pressure , uterine artery , endocrinology , placenta , anesthesia , cerebral perfusion pressure , pregnancy , cardiology , fetus , gestation , biology , genetics
Coffee is one of the most widely consumed beverages in the world, and caffeine is the most studied compound in coffee. Coffee consumption is associated with a decreased risk of preeclampsia. Preeclampsia is a hypertensive disorder of pregnancy, and under‐perfusion of the placenta is hypothesized to contribute to the disease. An animal model of preeclampsia is the reduced uterine perfusion pressure (RUPP) model. The focus of this study was to investigate if caffeine prevents peripheral vascular function dysfunction, specifically the posterior cerebral artery (PCA), in the RUPP model. Pregnant rats were divided into three groups: control pregnant, RUPP, RUPP + caffeine (~10µg/day via drinking water). Near term, maternal PCAs were studied in a pressurized arteriograph. The diameter of each artery was measured in HEPES buffered saline solution with and without calcium. Percent tone was calculated for each artery at each pressure step (25‐200mmHg). The tone of the PCAs isolated from controls was significantly lower (ex. 125mmHg, 8.7±1.9%) than tone exhibited by the PCAs isolated from RUPP animals (14.6±6.1%). Conversely, caffeine prevented the increase in tone induced in the RUPP model (5.1±1.9%). Caffeine treatment prevents the increase in tone induced in the RUPP model. These data suggest a protective effect of caffeine on cerebral vascular function during pregnancy, and may have relevance to preeclampsia.