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Cerebral hemodynamics in normal aging: associations with central hemodynamics and cerebral small vessel disease (1069.2)
Author(s) -
Tarumi Takashi,
Ayaz Muhammad,
Liu Jie,
Tseng Benjamin,
Parker Rosemary,
Jonathan Riley,
Tinajero Cynthia,
Zaidi Waqar,
Zhang Rong
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1069.2
Subject(s) - pulsatile flow , medicine , cerebral blood flow , hemodynamics , arterial stiffness , cardiology , hyperintensity , cerebral arteries , blood pressure , pulse pressure , magnetic resonance imaging , radiology
Background : Blood ejected from the left ventricle perfuses the brain via central elastic arteries, which stiffen with advancing age and may elevate the risk of end‐organ damage. The current study aimed to determine the impact of central arterial aging on cerebral hemodynamics. Methods : Ninety participants aged 22‐80 years were enrolled. Total and pulsatile cerebral blood flows (CBF) were measured by phase‐contrast MR imaging and transcranial Doppler respectively. Central arterial stiffness, wave reflection, and pressure were recorded using applanation tonometry. White matter hyperintensity, a marker of cerebral small vessel disease, was measured by fluid‐attenuated inversion recovery MR imaging. Results : Total CBF decreased with age while systolic and pulsatile CBF increased and diastolic CBF decreased. In the frequency domain, CBF pulsatility at the fundamental harmonic exhibited a steep curvilinear increase with age. Age‐related differences in CBF pulsatility were independently associated with carotid pressure pulsatility. In middle‐aged and older subjects, the prevalence of white matter hyperintensity increased with age and was independently associated with CBF pulsatility. Conclusions : Central arterial aging plays an important role to determine age‐related differences in cerebral hemodynamics. Cerebral small vessel disease is more closely associated with pulsatile CBF than total CBF. Grant Funding Source : National Institute on Aging