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Gender comparison of recovery from intravenous and inhalational anaesthetics among adult patients in South‐West Nigeria (1064.3)
Author(s) -
OkunorenOyekenu Yewande,
Sanusi Arinola,
Gbotosho Grace
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1064.3
Subject(s) - isoflurane , propofol , pharmacokinetics , halothane , anesthesia , medicine , plasma concentration , high performance liquid chromatography , chemistry , pharmacology , chromatography
Gender is a known factor in recovery from general anaesthetics. This study reports such a difference in South‐West Nigerian patients, and proposes gender‐based differences in pharmacokinetic profiles as explanation. Two main strata (20 males and 20 females) were considered, and written informed consents were obtained for both strata. Intravenous general anaesthesia was induced with propofol or thiopental and maintained with inhalational agent halothane or isoflurane. Patient plasma samples were analyzed with high performance liquid chromatography (HPLC), for anaesthetic agents before induction; at 10, 30 60, 180 mins after induction of anaesthesia, and at recovery. The Elimination Half Life, Mean Resident Time, and Clearance measured in propofol patients maintained on halothane or isoflurane were 310.7 ± 138.4 min, 459.2 ± 199.4 min and 431.1 ± 154.1 ml/min, respectively for females versus 503.0 ± 312.2 min, 732.8 ± 448.3 min and 290.0 ± 157.8 ml/min for males. The corresponding values with thiopental induction were 148.0 ± 112.7 min, 220.9 ± 180.3 min and 544.6 ± 500.1 ml/min for females versus 76.8 ± 28.7 min, 115.4 ± 35.4 min and 533.7 ± 502.5 ml/min for males. Data was significantly different (p<0.05) across gender. Gender differences in recovery from anaesthetic agents in Southwest Nigerian patients is due to differences in pharmacokinetic profiles. Anaesthesia, Recovery time, HPLC, Pharmacokinetics.Grant Funding Source : Self‐Funded Research Student supported by Supervisors