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Piperine and ketoconazole increase plasma domperidone concentrations in the rat (1064.2)
Author(s) -
Alhumayyd Mohammad,
Bukhari Ishfaq,
Almotrefi Abdulrahman
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1064.2
Subject(s) - piperine , domperidone , ketoconazole , pharmacokinetics , pharmacology , chemistry , plasma concentration , medicine , endocrinology , dopamine , antifungal , dermatology
This study was carried out to investigate the effect of piperine, a major pungent constituent of the black and red peppers and ketoconazole on the pharmacokinetics of domperidone. Animals received a single dose of domperidone(20mg/kg, p.o.) alone or together with piperine (60mg/kg, p.o.) or ketoconazole(50 mg/kg, p.o.) daily for 5 days. Plasma samples were collected at 0.25, 0.5, 1.0, 2.0, 3.0, 4.0, 6.0, 8.0, 10.0 and 12h after drug administration. The concentrations of domperidone in the plasma were measured using an HPLC method. The concomitant administration of piperine or ketoconazole with domperidone resulted in a significant (p<0.05) increase in the maximum plasma concentration(C max ), the mean area under the plasma concentration‐ time curve(AUC), and the elimination half‐life(t 1/2 ) of domperidone as compared to those obtained for domperidone alone. These results suggest that an important pharmacokinetic interaction may occur if piperine or ketoconazole are administered concurrently with domperidone.