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Hyperbaric oxygen suppresses paclitaxel‐induced cold allodynia in rats (1061.2)
Author(s) -
Zhang Yangmiao,
Nelson Jordan,
Shirachi Donald,
Quock Raymond
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1061.2
Subject(s) - allodynia , hyperbaric oxygen , medicine , anesthesia , nociception , hyperalgesia , pharmacology , chemistry , receptor
HBO 2 treatment can relieve chronic pain (Thompson et al. , Neurosci Res 66:279, 2010). Previously, we reported that HBO 2 suppressed PAC‐induced mechanical allodynia (Zhang et al. , FASEB J 26:662.9, 2012). The aim of this study was to determine whether HBO 2 treatment could also reduce PAC‐induced cold allodynia. Male Sprague Dawley rats, 250‐350 g, were injected intraperitoneally with either 1.0 mg/kg PAC or vehicle on days 0, 2, 4 and 6. On day 7, rats were treated with 60‐min HBO 2 at 3.5 atmospheres absolute (ATA) or room air for either one or four days. Cold allodynia was assessed every other day by applying 50 µL acetone to each hind paw. Allodynia was scored using a 0‐3 point scale. Results showed that PAC‐treated rats developed cold allodynia in response to acetone. A single 60‐min HBO 2 treatment at 3.5 ATA did not produce obvious recovery from allodynia. However, allodynia was suppressed in rats that underwent four daily 60‐min HBO 2 treatments. These results indicate that, while one HBO 2 treatment is not sufficient to reduce PAC‐induced cold allodynia, repeated (4×) HBO 2 treatment can suppress the development of PAC‐induced cold allodynia. Grant Funding Source : Supported by NIH Grant AT‐007222 and the Allen I. White Distinguished Professorship.