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Ursolic acid, a promising dietary bioactive compound of anti‐obesity (1045.40)
Author(s) -
Wang Yanwen,
He Yonghan
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1045.40
Subject(s) - ursolic acid , ampk , adipogenesis , chemistry , beta oxidation , protein kinase a , adipose tissue , biochemistry , phosphorylation , lipolysis , endocrinology , thermogenesis , fatty acid , medicine , biology , chromatography
Ursolic acid has recently been reported to possess a promising anti‐obesity effect. A number of studies have been conducted to elucidate the underlying mechanisms, which include the inhibition of pancreatic lipase activity, promotion of muscle hypertrophy, increase of brown fat, thermogenesis, energy expenditure, and lipolysis. Our recent study in 3T3‐L1 preadipocytes has demonstrated that ursolic acid inhibits cell differentiation and adipogenesis. This compound modulates the expression or activity of many proteins or enzymes involved in fat cell differentiation, fatty acid synthesis and oxidation. Further studies have shown that ursolic acid increases the phosphorylation and activity of AMPK and the protein expression of Sirt1. The anti‐adipogenic effect of UA can be reversed by AMPK siRNA but not Sirt1 inhibitor. Moreover, when LKB1 is silenced or inhibited, the effect of UA on AMPK activation diminishes. These results demonstrate that ursolic acid inhibits preadipocyte differentiation and adipogenesis through LKB1/AMPK pathway. While focusing on our recent report on the effect and mechanism of action of ursolic acid on fat cell differentiation and adipogenesis, other mechanisms related to energy and fat metabolism and body weight will be briefly discussed. Grant Funding Source : CIHR