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Enhanced oral bioavailability of quercetin by nanostructured lipid carriers (1044.24)
Author(s) -
Sun Ming,
Wang Shu,
Nie Shufang,
Zhang Jia
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1044.24
Subject(s) - quercetin , bioavailability , flavonoid , chemistry , solubility , chromatography , pharmacokinetics , oral administration , high performance liquid chromatography , pharmacology , antioxidant , biochemistry , medicine , organic chemistry
Background: Quercetin, a flavonoid found in fruits, vegetables and grains, has been shown to have many biological activities and pharmacological actions, however, because of its high hydrophobicity, low stability, and low oral bioavailability, the clinical application of quercetin is greatly restricted. We have successful synthesized biocompatible and biodegradable quercetin loaded nanostructured lipid carriers (QNLCs) and chitosan‐coated QNLCs (CS‐QNLCs), which may improve the solubility, stability and bioavailability of quercetin. Methods: The solubility of quercetin in water and its stabilities in plasma and different gastric‐intestinal solutions were measured using a HPLC system in vitro. Native quercetin, QNLCs and CS‐QNLCs were given through intravenous or oral administration to male SD rats. Quercetin concentrations in blood at different time points were measured using a HPLC system. Results: As compared to native quercetin, QNLCs and CS‐QNLCs increased quercetin stability in plasma and gastric‐intestinal solutions. Q‐NLCs and CS‐QNLCs significantly increased AUC (area under plasma concentration‐time curve) values with prolonged blood circulation time compared with native Q. Conclusion: Nanoencapsulation significantly increased quercetin aqueous solubility, stabilities in plasma and gastric‐intestinal solutions, and bioavailability. Grant Funding Source : Texas Tech University