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High rates of riboflavin deficiency in women of childbearing age in Cambodia and Canada (1041.12)
Author(s) -
Whitfield Kyly,
McCann Adrian,
Karakochuk Crystal,
Talukder Aminuzzaman,
Ward Mary,
McNulty Helene,
McLean Judy,
Green Tim
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1041.12
Subject(s) - riboflavin , flavin adenine dinucleotide , glutathione reductase , flavin mononucleotide , flavin group , medicine , environmental health , chemistry , endocrinology , cofactor , biochemistry , enzyme , superoxide dismutase , oxidative stress , glutathione peroxidase
High rates of riboflavin deficiency in women of childbearing age in Cambodia and Canada Whitfield, KC 1 , McCann, A 2 , Karakochuk, C 1 , Talukder, A 3 , Ward, M 2 , McNulty, H 2 , McLean, J 1 , Green TJ 1 (1) Department of Food, Nutrition, and Health, University of British Columbia, Canada (2) Northern Ireland Centre for Food and Health, University of Ulster, Northern Ireland (3) Helen Keller International, Phnom Penh, Cambodia As an integral component of the coenzymes flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), riboflavin is essential for metabolic homeostasis. Limited evidence is available comparing riboflavin status among individuals from developed and developing countries. We conducted two cross‐sectional studies with apparently healthy non‐pregnant, non‐lactating women of childbearing age (20‐45y), on a representative sample from urban Phnom Penh (n=146) and rural Prey Veng (n=156), Cambodia, and a convenience sample of urban women in Vancouver, Canada (n=51). As a functional biomarker of riboflavin status, erythrocyte glutathione reductase activity coefficient (EGRac) was measured. Among Cambodian women, riboflavin deficiency (EGRac 蠅1.4) was prevalent (Prey Veng, 82%; Phnom Penh, 78%). Although a significantly higher proportion of Canadian women were riboflavin sufficient (EGRac 蠄1.3; p<0.001), 67% of Canadians had a suboptimal riboflavin status (EGRac >1.3). The data suggests suboptimal riboflavin status and deficiency may be widespread in both developed and developing countries and merits further investigation. Grant Funding Source : Supported by the University of British Columbia Vitamin Research Fund