The relationship between vitamin D status and markers of diabetes risk in individuals at risk for developing diabetes: preliminary data from the Evidence trial (1041.10)

Data from epidemiological studies show an inverse association between low levels of serum 25‐hydroxyvitamin D 3 (25(OH)D 3 ) and markers of diabetes risk including high blood glucose levels. The EVIDENCE trial is a randomized, double‐blind clinical trial which aims to examine the effect of vitamin D 3 fortified cheese versus placebo on fasting and serum glucose 2h after consuming 75g of glucose (OGTT), insulin, glycated haemoglobin (HbA1c) and markers of inflammation in subjects with low serum 25(OH)D 3 (蠄65nmol/ L) and who are at an increased risk for developing type 2 diabetes (T2D) . Twenty‐one subjects (11M, 10F) with a mean age of 52 ± 12y enrolled in the EVIDENCE trial visited the laboratory after a 12hr overnight fast. Fasting blood samples were drawn from subjects and assayed for 25(OH)D 3 , glucose, HbA1c, triglycerides, total, LDL and HDL cholesterol. In this sample of participants enrolled in the EVIDENCE trial we observed a significant inverse association between 25(OH)D 3 and triglycerides (r= ‐0.5413, p= 0.011) and waist circumference (r= ‐0.4427, p= 0.045). We also observed an moderate inverse association between serum 25(OH)D 3 and HbA1c (r= ‐0.270), however it was not statistically significant. No significant associations were observed between 25(OH)D 3 and glucose, total, LDL and HDL cholesterol which may be due to the small sample size. These preliminary data suggests that vitamin D status is inversely related to factors which increase an individual’s risk for developing diabetes.The results from the EVIDENCE trial will assist us in obtaining a better understanding of the potential role of vitamin D in modulating some of the risk factors associated with T2D. Grant Funding Source : Supported by Dairy Farmers of Canada