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Sorghum starch is well digested in developmental pancreatic α‐amylase insufficient children in Mali (1039.11)
Author(s) -
Cisse Fatimata,
Diall Hawa,
Rahmanifar Atossa,
Sylla Mariam,
Opekun Antone,
Grusak Michael,
Lin Amy,
Nichols Buford,
Hamaker Bruce
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1039.11
Subject(s) - sorghum , amylase , starch , digestion (alchemy) , food science , biology , medicine , zoology , chemistry , agronomy , gastroenterology , biochemistry , enzyme , chromatography
We hypothesized that moderately malnourished weaned stunted children have impaired ability to digest starch due to developmental pancreatic α‐amylase insufficiency that impedes their normal growth with typical foods used at home. An innovative non‐invasive modified 13 C‐breath test was used to assess the ability to digest starch in healthy (16) and moderately stunted infants (32) from 18 ‐ 30 months in Bamako, Mali. Common or modified sorghum porridges and three different 13 C substrates (UL‐algal starch, UL‐algal limit dextrins, and greenhouse‐enriched sorghum) were fed in five separate days. Serial breath samples (every 15 min for 3 hours) were collected and analyzed using a 13 CO 2 infrared spectrophotometer. The obtained results showed a pancreatic α‐amylase insufficiency in both healthy and moderately stunted groups. 90% of all subjects digested well the common sorghum porridge whereas the modified porridge with mechanical treatment presented a reduced digestion rate which was not corrected with further amylase pretreatment. We conclude that the digestion of sorghum porridge starches is poorly related to amylase insufficiency, and these starches are well digested via the mucosal α‐glucosidases in Malian moderately malnourished stunted weaned children.