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Early infant feeding and islet autoimmunity in The Environmental Determinants of Diabetes in the Young (TEDDY) Study (1038.5)
Author(s) -
Uusitalo Ulla,
Lee HyeSeung,
Andren Aroonsson Carin,
Vehik Kendra,
Yang Jimin,
Hummel Sandra,
Butterworth Martha,
Lernmark Ake,
Rewers Marian,
Hagopian William,
She JinXiong,
Simell Olli,
Ziegler Anette,
Akolkar Beena,
Krischer Jeffrey,
Virtanen Suvi M,
Norris Jill M
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.1038.5
Subject(s) - medicine , breastfeeding , islet , autoimmunity , diabetes mellitus , type 1 diabetes , genotype , immunology , pediatrics , endocrinology , immune system , biology , genetics , gene
This is the first attempt to study infant feeding in the development of type 1 diabetes (T1D) related islet autoimmunity (IA) in a multi‐country setting. The TEDDY study follows 8502 children with T1D‐associated HLA‐DR‐DQ alleles in Finland, Germany, Sweden and the US. Blood samples were collected every 3 months (m) from birth to evaluate IA, defined as appearance of one or more of the islet cell autoantibodies GADA, IAA, or IA‐2A confirmed at two consecutive visits. Information on infant feeding was collected by a questionnaire. We applied time‐to‐event analysis in this study. Breastfeeding duration was not associated with IA. Significant interactions between the HLA‐DR‐DQ genotype and diet were detected. Introduction of any solid food before 4 m was associated with increased IA risk (HR 1.73; 95%CI 1.04‐2.88) vs introduction at 蠅6 m, in HLA‐DR3/4 carriers. In non‐DR3/4 carriers, introduction of fruits/berries before 4 m was associated with decreased IA risk (HR 0.55; 95%CI 0.35‐0.86) vs introduction at 蠅6 m. We conclude that timing of solid food introduction may be associated with IA in TEDDY in a manner linked to HLA risk. Grant Funding Source : Supported by NIH, NIDDK, NIAID, NICHD, NIEHS, JDRF and CDC.